1. Set Up: Each player is dealt a hand of four Microbes cards. Place the remaining cards face down in the center of the playing area to form the draw pile.
2. Objective: The objective of the game is to be the first player to get rid of all their cards.
3. Playing a Round: The player to the left of the dealer starts the game by playing a Microbe card from their hand. The next player must then play a Microbe card that is either the same type of Microbe or a higher value Microbe. Play continues in a cLockwise direction until one player cannot play a card or chooses not to.
4. Drawing Cards: If a player cannot or chooses not to play a card, they must draw one card from the draw pile. They can then either play that card or pass their Turn to the next player.
5. Ending the Round: Play continues until one player has played all their cards. That player is the winner of the round and the other players must count the number of cards remaining in their hands.
6. ScoRing: At the end of the round, each player scores one Point for each card remaining in their hand. The player with the most Points at the end of the game is the winner.